Neuralstem’s cells reverse paralysis

Published: May 30, 2007 at 11:10 AM

Neuralstem’s cells reverse paralysis

ROCKVILLE, Md., May 30 (UPI) — U.S. firm Neuralstem said Wednesday its human spinal stem cells reversed paralysis in a rat model of a spinal disorder.

The company, which said the finding has significant implications for humans because the condition the rats suffered from also afflicts people, plans to file an investigational new drug application later this year.
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In the study, which is published online by the journal Neuroscience, three rats paralyzed from ischemic spastic paraplegia returned to near normal function six weeks after receiving Neuralstem’s human spinal stem cells.

Three other rats did not regain the ability to stand up but showed significant improvement in the mobility of their joints and muscle tone.

Ischemic spastic paraplegia, which is characterized by extreme spasticity and rigidity that leads to paralysis, sometimes results in humans following surgery to repair aortic aneurysms.

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