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* Running with, not from, cancer

http://www.startribune.com/local/east/132203933.html

Running with, not from, cancer

Article by: TIM HARLOW ,  Sunday, October 23, 2011

Don Wright, 70, plans to run a marathon in all 50 states, a goal he set eight years ago after he was diagnosed with an incurable form of cancer.

Don Wright, 70 didn’t begin running until he was 62, when he was diagnosed with multiple myeloma. Since then he has run 54 marathons in 36 states. Wright ran a practice run near his Lake Elmo home.

Marathon runners know that the 26.2-mile races provide plenty of opportunities for humbling moments. For Don Wright, the first occurs when the horn goes off and he crosses the starting line.

For Wright, 70, each race is another step in his battle to ward off multiple myeloma, a cancer that has no cure and often manifests itself through bone or back pain. It’s also an opportunity to raise money to help other cancer patients pay their medical bills.

“I get very emotional at the start, almost weepy,” said Wright, of Lake Elmo. “As I’m drifting past the scenery, I think about how fortunate I am and how I’m sticking my finger in the eye of the cancer.”

Since he was diagnosed with myeloma eight years ago, Wright has logged more than 1,400 miles in completing 57 marathons in 38 states. He’s won awards for first-place finishes in his age group and clocked times that allowed him to qualify for the prestigious Boston Marathon.

It’s always a thrill to cross the finish line, Wright said, but his proudest accomplishment has been making life better for others.

In each race — including the Marine Corps Marathon in Washington, D.C., on Oct. 30 and his second New York City Marathon on Nov. 6 — Wright runs for Team Continuum, a nonprofit that provides financial assistance to help cover daily living expenses for cancer victims and their families who are saddled with medical bills. Donations can be made at www.startribune.com/a721.

“Running for a great organization like Team Continuum is a way for me to help others lead better lives with cancer,” he said.

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Wright has already beaten those odds, and even though the cancer could sideline him any day, he jokes that his two most immediate concerns are runner’s knee and a sports hernia.

Wright has been able to keep myeloma’s ill effects at bay by skipping traditional chemotherapy and instead taking the experimental drug Pomalidomide daily. He makes monthly trips to the Mayo Clinic in Rochester for checkups. Running is his best form of physical therapy.

“The weight-bearing actually helps preserve bone density,” said Dr. Martha Lacy, Wright’s physician at Mayo who has studied the illness for more than 15 years. “He’s got lots of stamina and his attitude is amazing. He is focused on being well. He’s quite a guy.”

Although he ran cross country in high school, Wright only dabbled in running over the next few decades until he rediscovered his “runner’s urge” when he was in his early 60s, the age when myeloma is most likely to occur. He ran and completed his first marathon — Grandma’s in Duluth — in 4:30:11 in 2003. Just days later, he was diagnosed with the cancer.

“I was shocked. I had no symptoms,” said Wright, a former innovator at Maplewood’s 3M Co. “I thought ‘I have to hurry before it’s too late to run Boston.'”

He achieved that goal in 2004, clocking in at 4:16:07, which led to the larger goal of completing at least one marathon in all 50 states. He’s made it to 41 so far, cheered on by his biggest fans: his wife, Ardis, and daughter, Sarah, who run with him during most of his events.

Wright’s remarkable achievements — physically and medically — are giving doctors hope that one day there will be a cure for myeloma. While they still do not know what causes it, treatments such as Pomalidomide are allowing victims to live longer and maintain a higher quality of life, Lacy said.

“We have been impressed with the drug,” said Lacy, who noted that Wright is among 225 patients who are in a study group which allowed him to be put on the experimental drug. . “It doesn’t work for everybody, but there has been a high response,” Lacy said.

It’s not a cure-all, however, and symptoms could arise at any time. Wright said he has three hot spots in his bones and that makes him a bit nervous.

“There is just no way to know,” he said. “I have no intentions of letting that happen, but I’ve had a good life if that happens.”

Tim Harlow • 651-925-5039 • Twitter: @timstrib

* If You Can’t Get an Organ, an Organoid Might Do

http://gizmodo.com/5851454/if-you-cant-get-an-organ-an-organoid-might-do

Oct 19, 2011

If You Can’t Get an Organ, an Organoid Might Do

The line waiting for organ donors is 112,381 people long and growing, and 18 people daily die waiting. To help patients survive the interim, scientists are working on “organoinds”—mini organs that would temporarily operate outside the body.

Dr. Rober Hariri, a surgeon and CEO of Celgene Cellular Therapeutics, is using stem cells derived from placentas (a refreshingly non-conroversial source of stem cells), to build the temporary organs. He devised a method for implanting the stem cells into a tissue matrix made from cells taken from cadavers. If the matrix is made of, say, kidney cells, the stem cells will take cues from their environment and also transform into kidney cells.

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The drawing depicts stem cells being extracted from a placenta.

The resulting glob is a mini-organ that could temporarily perform the functions of a failing human liver, kidney, heart, and possibly any other human organ. The patients’ blood would be filtered through the organ through tubes.

“This could be the way we build replacement parts,” Hariri said.

You can check out their patent here. Hariri will talk more about his progress with organoids at the Tissue Engineering and Regenerative Medicine Society annual meeting in Houston in December.

[Images: Celgene, US Patent 7914779]

* 50 Marathons 50 States | 10/14

http://www.ctnow.com/videobeta/01438568-9708-430b-8687-5edea2adf7a2/News/50-Marathons-50-States-10-14

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* 70-year-old battling cancer completes 56th marathon

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PORTLAND, Maine (NEWS CENTER) — Among the thousands of runners who ran in the Maine Marathon, one 70-year-old runner was running for a cause very close to him.

Don Wright suffers from Myeloma, an incurable form of blood cancer.  When he was diagnosed in 2003, he set out to run a marathon in each of the 50 states.  The Maine Marathon is his 56th marathon in his 38th state. Wright is running for Team Continuum, a non-profit that raises money to help cancer patients and their families pay their bills.  His campain slogan is his goal: to “E-Race Cancer”.

“I like to think sometimes as I’m running along that I’m just sticking it right in the cancer’s eye,” Wright said.

Team continuum has a Facebook page, and for every “like” the page receives, $5 will be donated to the non-profit.

NEWS CENTER