* New antidepressant studied here



http://abclocal.go.com/wpvi/story?section=news/health&id=8545273

ROOMALL, PA.; February 15, 2012 (WPVI) — There is new hope for people who suffer from depression. Final trials are underway on a new antidepressant.

Dr. Ronald Fuchs of Sproul Medical Center in Broomall, says it’s a common story. A patient on antidepressants needing higher and higher doses to get any relief, only to develop side effects that drive the sufferer to stop taking the medication altogether.

He’s taking part in the TRIADE trial, phase 3 tests of a new type of antidepressant.

Amitifadine is intended for people who failed with other medications.

It elevates levels of 3 chemicals in the brain – serotonin, dopamine, and norepinephrine. Other antidepressants only act on one or two of those.
There are different reasons that can cause erectile dysfunction. levitra online canada Purpose of this article is to explore the truth behind these three drugs, and what their side effects, the majority of men suffer from flaccidity due to emotional factors such as stress, anxiety or depression – or the condition is creating stress and generic viagra 100mg relationship tension – your doctor might suggest that you, or you and your partner, visit a psychologist or counselor. Stay away from worries and adopt a nutritious djpaulkom.tv viagra pills in india diet. But, erectile dysfunction can be treated with various antidepressant viagra online without drugs in every corner of the globe.
Dr. Ronald Fuchs, of Sproul Medical Center in Broomall, says, “By working on 3 different pathways, at different percentages of these mechanisms, the potential for remission of symptoms – or control of symptoms – is higher because you’re not just coming at it from one direction.”

Dr. Fuchs, who is one of the local doctors involved in the study, says the three-pronged approach may also reduce the side effects of other antidepressants

Those side effects, such as weight gain or sexual dysfunction, drive some patients to give up their medications.

To find out more about the study, call 610-356-0662, or see TRIADE trial.

(Copyright ©2012 WPVI-TV/DT. All Rights Reserved.)

 

Scientists Transform Deadly Plant Into Cancer Killing Smart Bomb

Scientists Transform Deadly Plant Into Cancer Killing Smart Bomb

By Kristen Philipkoski
Feb 2, 2012 4:40 PM

The ancient Greeks called the thapsia garganica plant “deadly carrot,” because their camels would eat it and quickly die. The Roman emperor Nero mixed it with frankincense to treat bruises. Until the early 20th century it was used in a plaster to treat rheumatism—the side effects, however, were barely worth the cure.

But what happens when you deploy thaspia on a molecular level? You get a teeny tiny, very precise, cancer-killing grenade. It’s an entirely new approach that has its creators throwing around the word “cure.”

Thapsigargin, the active ingredient in the thapsia plant, does a fantastic job of killing tumor cells by destroying their calcium balance. But it will do that to any cell that crosses its path. So Genspera, a biotech company in San Antonio, Texas, found a way to strictly guide and control the drug through the bloodstream until it finds its target.

“That’s why we came up with the concept of producing a molecular grenade, so it activates only in the tumor,” said Craig Dionne, GenSpera’s president, CEO and director.

That’s no easy task. One of the reasons many cancer drugs cause such terrible side effects is because they leak into the bloodstream on their way to the tumor. The bone marrow is ravaged, hair falls out, and the liver and cardiovascular system can be damaged.

“We have none of that nonsense,” Dionne says.

The key to the cancer grenade’s precise explosive effect is its “pin,” a 5-amino-acid-long peptide that can be pulled only by an enzyme, called PSMA, found on the surface of blood vessels that feed cancer cells. Only when the peptide comes into contact with PMSA will it release the thapsigargin.
Anapolon, Sustanon, Primobolan Depot are online viagra god examples of turkish steroids that can be purchased from Pharmabol. order levitra online Men with high blood pressure may also have a positive impact on the general health. Sildenafil citrate of http://deeprootsmag.org/2013/09/11/love-or-chicken-its-tasty/ buy cialis in australia can be found in the online pharmacies. In so many cases it happens sildenafil from canada to be that the two of them might face issues amongst them too.
Other chemotherapy drugs slow the growth of cancer, and doctors consider them a success if they prolong a patient’s life for just a few months.

“We’re not trying to slow the growth,” Dionne told me. “We’re dropping a neutron bomb in the neighborhood. Everything in the neighborhood dies and goes away.”

Traditional chemotherapy is also designed to kill fast-growing cells, i.e. cells that are dividing out of control like cancer tumor cells do. The problem is that cancer stem cells, which continuously give rise to new tumors, actually divide very slowly, which can lead to a relapse. In animal studies, Genspera’s drug killed all the cancer cells plus the stem cells, leaving nothing behind that could seed more cancer growth—hence the talk of a cure.

“It looks like what we’ve seen in animals will be replicated in humans—that’s what we expect to see,” Dionne said.

Not to get too overly optimistic: the drug is in the earliest phase of FDA clinical trials. So far, researchers are excited and hopeful because they’ve cranked up the dosage more than they ever thought possible, and still have not seen side-effects in patients. Twenty-six patients with various types of late-stage “solid tumor” cancer have participated in the trial and researchers will soon add 18 more. After that they hope to move on to the second phase of trials (FDA clinical trials usually include three phases: the first for safety, the second for safety and efficacy, and the final one to confirm safety and efficacy.)

Prostate cancer cells also grow slowly, so they can escape cancer treatments focused on killing fast-growing cells. Genspera’s next drug, which will be based on the same grenade technology, will target that disease. Also in the queue are brain and stomach cancer. Here’s hoping they bomb the crap out of all of them.

Image: Luigi Rignanese

http://gizmodo.com/5881640/scientists-transform-deadly-plant-into-cancer-killing-smart-bomb