Targeted Cancer Drugs Keep Myeloma Patients Up And Running

Targeted Cancer Drugs Keep Myeloma Patients Up And Running

by Richard Knox
February 18, 2013 3:34 AM

http://www.npr.org/blogs/health/2013/02/18/172098789/targeted-cancer-drugs-keep-myeloma-patients-up-and-running

Don Wright got diagnosed with multiple myeloma at what turned out to be the right time. It was 10 years ago, when he was 62.

That was at the beginning of a revolution in treating this once-fearsome blood cell cancer, which strikes around 20,000 Americans every year. The malignancy can literally eat holes in victims’ bones, which can snap from the simple act of bending over to pick up a package.
The first treatment Wright had was thalidomide, the sedative that caused awful birth defects in the 1960s. But it didn’t work for long.

Then he got into a study of a related drug called pomalidomide. Earlier this month the Food and Drug Administration approved the drug, which will be marketed as Pomalyst.

Don Wright was diagnosed with multiple myeloma in 2003 only days after completing his first marathon. Since then he has run 70 marathons in all 50 states.

Not only has the drug kept the Minnesota man alive far beyond the three or four years typical for newly diagnosed myeloma patients not so long ago. But it’s also enabled him to keep running marathons.

In the decade since his diagnosis, Wright has averaged seven marathons a year. He’s training for his 71st, which will take place in March on Cape Cod.

“Yesterday I ran 18 miles inside of a soccer dome,” Wright said recently, “and then came back and shoveled snow for 2 1/2 hours. That was a big day.”

Wright was one of the first patients to get Pomalyst, back in 2006. “For me this has been a miracle drug,” he tells Shots. “It’s kept the myeloma stable. And it’s just a little pill.”

Pomalyst is the latest of a half-dozen myeloma drugs developed in the decade or so since Wright got diagnosed. Another, called Kyprolis, won FDA approval last summer.

Like many so-called “targeted” cancer therapies coming out these days, the new drugs are enormously expensive. Pomalyst will cost about $10,450 a month, or more than $125,000 a year.

Do not feel soft tadalafil ashamed or reluctant to seek help by a psychologist in case you feel the situation, share it with your girl so that she commits to stay by your side during the time you searching for the remedies. Lots of young adults are there who are passionate about oral sex, their sexual harmony is far greater than the estimated 18 million men reported cipla levitra to suffer from it. Additionally, some davidfraymusic.com online cialis of my dearest friends are like sisters to me. So, levitra purchase online do not limit your pet’s heart treatment to novox for dogs. Dr. Brian Durie of the International Myeloma Foundation says the availability of these new drugs has been transformative.

“It really has changed the whole landscape for both the doctor and the patient,” he says. “Ten or 15 years ago, it was very depressing to see a new myeloma patient because you knew that the life was potentially short and it was difficult to be overly optimistic about what might transpire.”

Wright is among the 20 to 30 percent of patients who have a less aggressive type of myeloma. But Durie says virtually all patients are benefiting from the new treatment options.

“We can say that 95 to 98 percent of the time we can pretty much guarantee we have a treatment that works — that the patient will go into a remission,” Durie says.

That’s pretty remarkable. But it’s not a cure. Eventually the first drug regimen — whatever it is — stops working and the cancer comes back.

But researchers think they’re on the verge of blocking myeloma’s return for good.
“We’re close, close, close,” says Dr. Ken Anderson of the Dana-Farber Cancer Institute in Boston. “We’re soon really going to change the natural history [of myeloma] in a major way.”

Don Wright shows the drug pomalidomide, which he has been taking as a participant in a clinical trial. Pomalidomide was recently approved by the FDA approved for treatment of multiple myeloma.

That’s doctor-speak for “cure.” Until specialists achieve that cure, they have an expanding bag of tricks to keep the cancer at bay.

New drug combinations and more novel drugs are coming along. Durie notes that scientists presented more than 700 papers on myeloma at December’s American Society of Hematology meeting.

In addition to the new medicines, many patients get stem-cell transplants in an attempt to obliterate nearly all the myeloma cells. But Anderson is leading an international study to determine whether the new drug regimens are so good that risky transplants aren’t needed any more.

“If somebody comes and sees us in the clinic,” Anderson says, “you can look them in the eye and say, ‘You know, it’s highly likely you’re going to live a decade or more. And frankly, with the maintenance therapy, it could be quite a lot longer.’ ”

Marathoner Don Wright has his own definition of a cure.

“The cure for myeloma,” he says, “is to hang on long enough to die of something else. And that is precisely my hope — and my plan, actually.”

You might say he’s in it for the long run.

Targeted Cancer Drugs Keep Myeloma Patients Up And Running


by Richard Knox
February 18, 2013 3:34 AM

http://www.npr.org/blogs/health/2013/02/18/172098789/targeted-cancer-drugs-keep-myeloma-patients-up-and-running

Don Wright got diagnosed with multiple myeloma at what turned out to be the right time. It was 10 years ago, when he was 62.

That was at the beginning of a revolution in treating this once-fearsome blood cell cancer, which strikes around 20,000 Americans every year. The malignancy can literally eat holes in victims’ bones, which can snap from the simple act of bending over to pick up a package.

The first treatment Wright had was thalidomide, the sedative that caused awful birth defects in the 1960s. But it didn’t work for long.

Then he got into a study of a related drug called pomalidomide. Earlier this month the Food and Drug Administration approved the drug, which will be marketed as Pomalyst.

Don Wright was diagnosed with multiple myeloma in 2003 only days after completing his first marathon. Since then he has run 70 marathons in all 50 states.

Not only has the drug kept the Minnesota man alive far beyond the three or four years typical for newly diagnosed myeloma patients not so long ago. But it’s also enabled him to keep running marathons.
In the decade since his diagnosis, Wright has averaged seven marathons a year. He’s training for his 71st, which will take place in March on Cape Cod.

“Yesterday I ran 18 miles inside of a soccer dome,” Wright said recently, “and then came back and shoveled snow for 2 1/2 hours. That was a big day.”

Wright was one of the first patients to get Pomalyst, back in 2006. “For me this has been a miracle drug,” he tells Shots. “It’s kept the myeloma stable. And it’s just a little pill.”

Pomalyst is the latest of a half-dozen myeloma drugs developed in the decade or so since Wright got diagnosed. Another, called Kyprolis, won FDA approval last summer.

Like many so-called “targeted” cancer therapies coming out these days, the new drugs are enormously expensive. Pomalyst will cost about $10,450 a month, or more than $125,000 a year.

Dr. Brian Durie of the International Myeloma Foundation says the availability of these new drugs has been transformative.
Also medications such as shop for viagra 100mg will help you be free from erectile dysfunction. The drug inhibits sildenafil nitrate which is the key cause of production davidfraymusic.com cheap sildenafil india of cholesterol. So we can have anything, whether contain the particle of sugar or not, we can convert this additional glucose through exercise. tadalafil viagra It’s recommended to take the drug before meal in order to get enhanced cialis super active sexual life.
“It really has changed the whole landscape for both the doctor and the patient,” he says. “Ten or 15 years ago, it was very depressing to see a new myeloma patient because you knew that the life was potentially short and it was difficult to be overly optimistic about what might transpire.”

Wright is among the 20 to 30 percent of patients who have a less aggressive type of myeloma. But Durie says virtually all patients are benefiting from the new treatment options.

“We can say that 95 to 98 percent of the time we can pretty much guarantee we have a treatment that works — that the patient will go into a remission,” Durie says.

That’s pretty remarkable. But it’s not a cure. Eventually the first drug regimen — whatever it is — stops working and the cancer comes back.

But researchers think they’re on the verge of blocking myeloma’s return for good.

“We’re close, close, close,” says Dr. Ken Anderson of the Dana-Farber Cancer Institute in Boston. “We’re soon really going to change the natural history [of myeloma] in a major way.”

Don Wright shows the drug pomalidomide, which he has been taking as a participant in a clinical trial. Pomalidomide was recently approved by the FDA approved for treatment of multiple myeloma.

That’s doctor-speak for “cure.” Until specialists achieve that cure, they have an expanding bag of tricks to keep the cancer at bay.

New drug combinations and more novel drugs are coming along. Durie notes that scientists presented more than 700 papers on myeloma at December’s American Society of Hematology meeting.

In addition to the new medicines, many patients get stem-cell transplants in an attempt to obliterate nearly all the myeloma cells. But Anderson is leading an international study to determine whether the new drug regimens are so good that risky transplants aren’t needed any more.

“If somebody comes and sees us in the clinic,” Anderson says, “you can look them in the eye and say, ‘You know, it’s highly likely you’re going to live a decade or more. And frankly, with the maintenance therapy, it could be quite a lot longer.’ ”

Marathoner Don Wright has his own definition of a cure.

“The cure for myeloma,” he says, “is to hang on long enough to die of something else. And that is precisely my hope — and my plan, actually.”

You might say he’s in it for the long run.

* Don Wright Interview by Dr. Sanjay Gupta

KOSIK: And every week, Dr. Sanjay Gupta brings us incredible stories of recovery and survival from around the world. In today’s “Human Factor,” our chief medical correspondent reports on a 71-year-old who’s continued his dream of running marathons while fighting a dangerous form of cancer, one where patients are rarely cured.

http://www.cnn.com/video/#/video/health/2013/01/09/human-factor-don-wright.cnn

SANJAY GUPTA, CNN CHIEF MEDICAL CORRESPONDENT: Don Wright’s career spanned engineering, being a company vice president, and the law. At age 62, he discovered a new passion — marathons. Nine year ago, days after running his first 26-mile race, he got some devastating news.

DON WRIGHT, MARATHON RUNNER/CANCER PATIENT: I had gone to the doctor a couple of times for pain in my back. It was multiple myeloma.

GUPTA: This is a cancer of the blood where the white blood cells invade the bone marrow causing pain, usually in the back or the ribs. Patients are rarely cured. But Wright refused to let that slow him down, even qualifying for the Boston marathon.

WRIGHT: We got this devastating diagnosis, and we just — my family and I, we just kept on going. You know, there wasn’t any reason to stop and be sorry, you know. We kept running marathons.

You would very rarely come across an Extenze customer review that cialis online shop would not recommend you to go ahead in their love-life. It causes hair loss Hair loss is a genetically determined, complicated process and in no way is testosterone replacement cialis no prescription cheap therapy responsible for it. Kamagra tablets also offer the same response however they take 45 to generic soft cialis find this 60 minutes to become fully effective. Human bladder is a place where viagra uk urine is stored. GUPTA: On December 9 under a hot Hawaiian sun, Wright, now 71, reached his seemingly impossible goal — running a marathon in all 50 states.

WRIGHT: It feels wonderful, I’ll tell you. A philosophy of life that I have is live one day at a time and make it a masterpiece, and that was a masterpiece.

GUPTA: Wright wasn’t sure he could fulfill his dream because the median survival for his cancer is just five years. Prognosis does vary depending on age and stage of the disease. He’s had a number of treatments that have failed. But for the last four-and-a-half years, Wright’s taken an experimental drug, one pill at night, that’s worked. It’s kept the cancer at bay.

WRIGHT: It doesn’t cure the cancer, but it keeps it stable so it’s not hurting me. And I can still run. And I can still enjoy life, and I’m riding that for all it’s worth.

GUPTA: His advice to others facing what seemed like insurmountable odds, take charge of your own destiny and never give up hope.

Dr. Sanjay Gupta, CNN, reporting.

* A Minnesota man who has incurable cancer hits a big milestone

http://www.kvue.com/news/182916671.html

by WCNC

kvue.com

Posted on December 10, 2012 at 8:43 PM
Updated Tuesday, Dec 11 at 7:18 AM

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A Minnesota man who has incurable cancer hits a big milestone.

Seventy-one-year-old Don Wright reached his goal of running marathons in all 50 states. He hit 50 this Sunday in Honolulu.

“My family and I have been running marathons in every state, and that’s been our goal, and we’ve run marathons now in 49 of the 50 states,” Wright said before the race on Sunday, “The diagnosis for my cancer was a three to five-year median survival. It feels like when I’m running along in a marathon, I’m just sticking my finger right in that cancer’s eye.”

Wright has a type of blood cancer.

He says he’s been able to control his battle thanks to a drug that’s being used in clinical trials.

And, he says he’ll keep running as long as he can.

* Cancer survivor runs his 50th marathon in the 50th state

http://www.hawaiinewsnow.com/story/20292980/cancer-survivor-runs-his-50th-marathon-in-the-50th-state

Cancer survivor runs his 50th marathon in the 50th state

Posted: Dec 07, 2012 10:42 PM EST Updated: Dec 08, 2012 1:43 AM EST

By Teri Okita – bio | email

HONOLULU (HawaiiNewsNow) –

Come Sunday morning, organizers are expecting more than 31,000 runners at the Honolulu marathon. In that crowd, a Minnesota man will, appropriately, be running his 50th marathon in the 50th state.

But Hawaii News Now found out: there’s much more to his story.

Don Wright has had plenty of practice crossing the finish line. This Sunday, he’ll have run a 26.2 mile marathon in every state in the nation.

“That’s pretty. I can’t wait ’til I’m running under that!” says Wright – as he looks at the finish line sign that’s not even hung up yet.

At age 71, not many people can say they’ve finished one marathon – let alone 50. It’s pretty impressive for a guy who just picked up running decade ago.

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Age is the least of his challenges. The St. Paul-area man was diagnosed with multiple myeloma – a blood cancer that affects cells in bone marrow. He was given about five years to live – that was nine years ago.

Running became his path to survival.

“It gives me a chance to make a point that people who have cancer can still have active, vital lives,” he says.

When Wright crosses the finish line on Sunday, he figures he will have logged 12,000, maybe 13,000, miles training and running these marathons.

Do the math. That’s like running from one coast to another – Los Angeles to New York – almost five times! His last marathon was just five weeks ago, and in 2011, he ran more than one marathon a month.

“He’s a runner, not a myeloma victim,” says his wife, 73 year old, Ardis. The Wrights and their daughter often race with together.

He’s stabilized on an investigative cancer drug called pomalidomide and needs no infusions or transplants. “We’re free because all he has is that little pill bottle, and he takes one pill every night and we can go,” says Ardis.

And go they do – successfully on the run from cancer.

Copyright 2012 Hawaii News Now. All rights reserved.

* Man with incurable cancer looks to complete quest to run marathons in all 50 states

Man with incurable cancer looks to complete quest to run marathons in all 50 states

Reported by: Olena Heu

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Click here to read the full article and see the video

One of the participants in Sunday’s Honolulu Marathon has overcome many obstacles to get here. The Minnesota resident was diagnosed with an incurable cancer.

Don Wright, 71, says he loves to run.

“I feel like I am floating past the scenery and just gliding along watching it go by,” Wright said.

Nearly 10 years ago, just days after Don’s first marathon, he was diagnosed with myeloma, which is a cancer of the blood.

“The diagnosis for my cancer was a three-to-five year median survival,” Wright said.

Inspired not to let the disease keep him down, the Minnesota resident decided to keep running.

“My family and I have been running marathons in every state. That’s been our goal and now we’ve run marathons in 49 of the 50 states,” Wright said.

When he completes the Honolulu Marathon on Sunday Don will achieve his goal of running 50 marathons in all 50 states…in the 50th state.

“It feels like when I am running along in a marathon like I have just stuck my finger right in that cancer’s eye,” Wright said.

Don runs with the hope of raising funds and awareness for The Tackle Cancer Foundation and has been able to control his battle with cancer thanks to a drug currently being used in clinical trials for his condition.

“That has kept it stable for five years and I actually feel very good,” Wright said.

Will this be his last marathon?

“This will never, no, no I will keep running marathons until I can’t, and that’s hopefully a long way off,” Wright said.

Click HERE to view Wright’s running blog.

* 50-state marathon runner stops in N.M.

50-state marathon runner stops in N.M.

http://www.koat.com/news/new-mexico/albuquerque/Marathon-Man/-/9153728/17072524/-/4xbrdv/-/index.html

Despite incurable cancer, man runs in dozens of marathons
Published 10:02 AM MDT Oct 21, 2012
ALBUQUERQUE, N.M. –
A Minnesota man diagnosed with an incurable form of cancer is on the run of his life as tries to run 50 marathons in 50 states.

Action 7 News reporter Tanya Mendis spoke with Don Wright on Sunday about his drive to keep running no matter what.

Wright said he was diagnosed with myeloma at 62. Nine years later, the 71-year-old has run marathons in 48 states.

Wright said he hopes to make New Mexico his 49th state.

“When I run, to be honest, I feel like I’m poking that cancer right in the eye,” Wright said.

So far he has run 69 marathons in 48 states.
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“I’d like people to be healthy and think healthy and if I’m an inspiration, that’s all the better,” Wright said.

He said he wouldn’t been able to run more than a few miles, if not for a special trial cancer drug he began four years ago.

“Which for me has turned out to be a miracle drug. It keeps the cancer stable, it doesn’t cure the cancer but it keeps it at a level where the cancer doesn’t hurt me,” Wright said.

He said he might not ever fully escape his cancer but he’s giving it the race of his life.

“The cancer numbers went down to about one-third of what they were to where it’s safe,” Wright said.

Wright did admit that he’s a little old to be running five or six days a week but he doesn’t plan to stop running marathons.

Wright will take part in the Duke City Marathon on Monday.
He said he plans on running his 50th and final state in Hawaii in December.

After that, he might try Canada.

* Sioux Falls Marathon attracts runners of all ages

KSFY (ABC, Sioux Falls, SD)

Sioux Falls Marathon attracts runners of all ages

http://www.ksfy.com/story/19496437/sioux-falls-marathon-attracts-runners

Posted: Sep 09, 2012 5:35 PM EDT Updated: Sep 09, 2012 7:06 PM EDT

2,000 runners ran a marathon in Sioux Falls today, including Don Wright, 71. He’s running a marathon in each of the 50 states.

He’s a cancer survivor and since his diagnosis 9 years ago, he’s run 66 marathons since being told he had a rare form of blood cancer.

He’s run over 1,500 miles, but he says his biggest complaint in this more than 26 mile race is runner’s knee.

“It’s a goal that keeps me going and it’s important to me and it’s my way of sticking that cancer right in the eye,” Wright said.

Wright is planning to run in Hawaii in December.

He’s also running in Alaska and New Mexico.

He has a blood cancer that affects cells in the bone marrow and can damage bones.
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It cannot be cured but luckily he can avoid chemo by taking medication and he’s able to train for these marathons.

The Sioux Falls marathon takes dozens and dozens of volunteers to make this marathon happen.

Some runners who took part in the race today came from all over the United States and around the country.

Volunteers tell us they met runners from New York and even Sweden.

“When you can get people from all over the U.S. and other countries it’s definitely going to help and Sioux Falls is a prosperous city. It has shown that with the promotion they have been doing,” Dave Tuch said.

Along with the marathon and half marathon today, there was also the Miracle 5k which raises money for the Children’s Miracle Network at Sanford Children’s Hospital.

The money raised will help sick kids in our area.

Some streets were closed in Sioux Falls because of this marathon.

Downtown street like Phillips Avenue, along with parts of Western Avenue.

Even the on and off ramps of Interstate 229.

* Goal: 50 states, 50 marathons

Goal: 50 states, 50 marathons

Cancer survivor checks off Vermont

8:50 AM, Jul 7, 2012
Written by JOHN A. FANTINO
Free Press Staff Writer

Don Wright of Minnesota will run in Sunday's Mad Marathon in Waitsfield.Diagnosed with an incurable blood cancer, Don Wright was told by doctors he had just a few years to live. That was nine years ago.

Since then, the 71-year-old from Lake Elmo, Minn., has run 63 marathons in 45 states, an impressive feat that he’s scheduled to continue Sunday when he runs the Mad Marathon in central Vermont.

“I’m not just surviving,” Wright said. “I’m thriving.”

Wright has multiple myeloma, a disease that attacks white blood cells and often comes with a death sentence.

“They said the average survival was five years,” Wright said. “You start getting your house in order pretty quick when you hear that.”

He also started cranking out training miles and marathon applications. For someone who started running when he was 61 simply to lose a few pounds, Wright soon completed his first marathon. Two weeks after being diagnosed with multiple myeloma, he qualified for the Boston Marathon.

Wright has been attempting to run a marathon in each of the 50 states, a mission he’s scheduled to complete this year.

The inspiring tour continues Sunday at the Mad Marathon, a 26-mile hilly trek through the Mad River Valley. The Mad Marathon, which debuted last year, starts and finishes in Waitsfield. The course snakes through rolling farmlands, quaint villages, dirt roads and covered bridges.

For Wright, each step of the race will represent success in his battle against cancer.

Opting not to undergo chemotherapy because it would make him too weak to train, Wright instead turned to the trial-drug pomalidomide several years ago.

“It’s just a pill,” Wright said. “I’d like to inspire the country to make available drugs like this for people who are dying. Accessibility to experimental drugs is important to me because it is saving me life.”

Wright, a lawyer, travels to many of the races with his wife Ardis and daughter Sarah, both of whom participate in half marathons while he runs the full marathons. They drive to many of the events, although they flew to Alaska last week to run a marathon.

What does Wright plan to do after running marathons in New Hampshire, New Mexico, West Virginia and Hawaii this year to complete the journey of 50 marathons in 50 states while fighting cancer?

“There’s a lot of Canada we haven’t explored yet,” he said.

To read the full article  click here…

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* Man with Terminal Cancer has Extraordinary Mission

Surviving Cancer One Marathon at a Time

Man with Terminal Cancer has Extraordinary Mission

By Wendi Jonassen, APRN – Anchorage | June 26, 2012 – 11:45 am

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When Don Wright was diagnosed with myeloma, a kind of terminal blood cancer, nine years ago, the average survival rate was only five years. Wright had run the Boston Marathon before the diagnosis and decided to not let cancer stop him. Over the next few years, Wright continued to run marathons, often visiting different states to do them. With the support of his wife and daughter, he set a goal to run a marathon in every state. The Mayor’s Marathon in Anchorage, Alaska marked his 45th state this last Saturday. He will finish all fifty this December in Hawaii where he will also be celebrating his 50th wedding anniversary.